Implementing and using viral load testing : practical tools

The 1st of September UNITAID’s Executive Director, Lelio Marmora, signed Phase II of OPP-ERA Project for three more years, in the presence of the consortium representatives at Solthis’ head office in Paris, committing a further US$ 14.7 million .

This project aims to expand access to viral-load testing at an affordable price in West and Center Africa. This innovative initiative is led by a consortium of French partners: Solthis, Expertise France, Sidaction and the ANRS. The second three-year phase aims to expand access to viral-load in four countries: Burundi, Cameroon, Ivory Coast and Guinea.

A viral-load test is the only way to know if a treatment for HIV is successful, and the only way to diagnose HIV infection in new-born babies. A lack of viral load access could undermine global efforts to diagnose and treat people living with HIV. In 2014, UNAIDS set a target that by 2020, 90 per cent of all people living with HIV should know their status, 90 per cent of those diagnosed should receive antiretroviral treatment and 90 per cent of those treated should have durable viral suppression , which is the hallmark of an effective treatment.

OPP-ERA, which has been running in Burundi, Cameroon, Ivory Coast and Guinea since March 2013, promotes access to Open Polyvalent Platforms (OPPs) – an innovative open laboratory system that enables HIV viral-load testing as well as a host of molecular tests to diagnose tuberculosis and viral hepatitis. The system is flexible, rapid, and easy to use and maintain for trained technicians, with machines suited to health clinics in both centralised and remote regions.

Access to HIV treatment and care in Western and Central Africa lags behind Eastern and Southern Africa. Whereas globally 17% of the people living with HIV live in Western and Central Africa, one in 4 AIDS deaths and 40 per cent of child deaths from AIDS occur in these regions.

The OPP-ERA project is starting to fill the gap in four countries. For example, by the end of the first phase of the project, more than 20 per cent of people on HIV treatment in Burundi had been tested for viral load. The second phase should allow a faster access to viral load in these countries. It should also enable research teams to demonstrate the polyvalence and effectiveness of the OPPs at national level.

The project will focus on stimulating manufacturers and suppliers to enter the market for viral-load testing, on growing demand for tests, and on demonstrating the benefits of open platforms to provide testing, even in places with relatively low HIV prevalence” said UNITAID’s Executive Director Lelio Marmora.

We are proud of this project, which brings together the scientific expertise and operational know-how of French actors today in West Africa, along with national partners committed to improving access to viral load” said Louis Pizarro, Executive Director of Solthis.

The OPP model promoted by the OPP-ERA project is already being widely adopted. The Global Fund is now procuring Open Polyvalent Platforms and is looking to the OPP-ERA project for its tools and training. 17 other countries outside the project have recently invested in OPPs technology, which should stimulate manufacturers to enter the market, increasing competition.

UNITAID contributes to the OPP-ERA project, which is co-financed and implemented by a consortium of French partners: Solthis (Solidarité Thérapeutique et Initiatives pour la Santé) handles coordination and implementation in Guinea, ANRS (France recherche Nord&sud Sida-hiv Hépatites) handles scientific direction and promoting results, Expertise France for implementation in Cote d’Ivoire and Cameroon, and Sidaction for implementation in Burundi.

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UNITAID extends the OPP-ERA project for HIV viral load testing for three years

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Michèle Boccoz, the French health ambassador in charge of HIV and communicable diseases visits the CePRef laboratory, a key partner of OPP-ERA project in Ivory Coast

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Michèle Boccoz, the French health ambassador in charge of HIV and communicable diseases visits the CePRef laboratory, a key partner of OPP-ERA project in Ivory Coast